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第1章:绪论和生命的生物化学
课时1：1.1Week 1 Introduction
01:00
课时2：1.2Medical Revolutions in Biology
07:21
课时3：1.3Biological applications in forensics, history, and agriculture
08:22
课时4：1.4The diversity of life
06:38
课时5：1.5An overview of evolution and a comparison of prokaryotic and eukaryotic cells
08:24
课时6：1.6The fundamental principles and intellectual framework of biology
19:12
课时7：1.7Fractionating life
14:35
课时8：1.8Molecular composition of cells
05:15
课时9：1.9Covalent bonds
10:09
课时10：1.10Non-covalent bonds
08:49
课时11：1.11Lipids and phospholipids
15:26
课时12：1.12High energy molecules：ATP and carbohydrates
08:19
课时13：1.13Reading Chemical Structures
05:42
课时14：1.14Polarity of Molecules
07:33
课时15：1.15Intermolecular Bonding
07:38
课时16：1.16How to Use the Molecule Editor
04:08
第2章:生化蛋白质、酶、糖酵解
课时1：2.1Week's Introduction
01:21
课时2：2.2Amazing proteins：primary structure
10:06
课时3：2.3Meet the amino acids
17:49
课时4：2.4Amazing proteins：secondary structure
08:33
课时5：2.5Amazing proteins：tertiary and quaternary structure
13:46
课时6：2.6Design a channel protein
10:04
课时7：2.7Enzymes and biochemical reactions
11:37
课时8：2.8What do enzymes do
05:47
课时9：2.9How do enzymes work
15:59
课时10：2.10Influenza virus - tricks of a burglar
11:36
课时11：2.11The energetics of pathways
15:29
课时12：2.12Logical tricks of pathways
08:02
课时13：2.13Glycolysis：a pathway to break down sugar
14:57
课时14：2.14Regulation of pathways
08:45
课时15：2.15Cellular respiration and fermentation
06:38
课时16：2.16Protein Purification - GFP
06:36
课时17：2.17Protein Purification - Beta-galactosidase
05:10
课时18：2.18X-ray Structure
05:53
课时19：2.19How to Explore a Protein
05:09
第3章:遗传学-孟德尔和T.H.摩根的工作
课时1：3.1Week's Introduction
01:07
课时2：3.2Background：Who was Mendel
11:38
课时3：3.3Mendel's Experiments
18:45
课时4：3.4Definitions
07:02
课时5：3.5Multiple traits：Mendel's second law
07:07
课时6：3.6Cytology and the chromosomal theory of inheritance
15:19
课时7：3.7Meiosis
12:50
课时8：3.8Fruit flies and linkage
20:06
课时9：3.9Linkage Maps
11:42
课时10：3.10Linkage Mapping
10:08
课时11：3.11Sex chromosomes and sex linkage
13:06
课时12：3.12Meiosis and the relationship to Punnett Squares
05:40
课时13：3.13Meiosis with two genes on different chromosomes
05:57
课时14：3.14Meiosis with two genes on the same chromosome
04:48
课时15：3.15Homologous recombination
07:08
课时16：3.16Modes of Inheritance with Flies
11:11
第4章:人类生化遗传学
课时1：4.1Week's Introduction
00:58
课时2：4.2X-linked recessive inheritance
17:54
课时3：4.3Autosomal dominant inheritance
15:51
课时4：4.4Autosomal recessive inheritance
06:12
课时5：4.5Real human genetics
15:51
课时6：4.6Garrod and inborn errors of metabolism
11:48
课时7：4.7Garrod, Beadle, Tatum and the link between genetics and biochemistry
07:11
课时8：4.8Yeast as a model organism
08:28
课时9：4.9How to use genetics to study biochemistry：A mutant hunt
11:13
课时10：4.10Tricks of a mutant hunt
12:43
课时11：4.11Characterizing Mutants：Tests of Dominance
03:02
课时12：4.12Characterizing Mutants：Tests of Complementation
15:41
课时13：4.13Characterizing mutants：epistasis test
09:51
课时14：4.14Yeast in the Lab
06:31
课时15：4.15Pedigree Analysis
06:49
第5章:分子生物学DNA复制
课时1：5.1Week's Introduction
00:51
课时2：5.2The Transforming Principle
16:50
课时3：5.3Structure of DNA∶ Nucleotides and Base-pairing
07:39
课时4：5.4Bacterial Viruses
12:01
课时5：5.5DNA Structure, The Race
18:20
课时6：5.6Meselson and Stahl
13:23
课时7：5.7Details of DNA Replication
09:42
课时8：5.8DNA Replication∶ Other Enzymes
09:05
课时9：5.9DNA Replication∶ Fidelity
11:17
课时10：5.10Kornberg's Enzyme
04:56
课时11：5.11Tour of a Nucleotide
03:42
课时12：5.12DNA Replication
07:26
第6章:分子生物学的转录，翻译，和变化
课时1：6.1Week's Introduction
01:00
课时2：6.2RNA
06:57
课时3：6.3Transcription∶ making RNA copy of DNA
13:02
课时4：6.4Translation∶ making a polypeptide from RNA
26:55
课时5：6.5Peering back in time
09:28
课时6：6.6Replication in different organisms
28:41
课时7：6.7Transcription in different organisms
16:32
课时8：6.8Translation in different organisms
07:03
课时9：6.9Beta-galactosidase in E coli
09:10
课时10：6.10Lac operon, lactose regulation
13:36
课时11：6.11Lac operon, glucose regulation
09:32
课时12：6.12Hormone receptors in mammals
02:55
课时13：6.13β-globin gene structure
11:54
课时14：6.14β-globin mutations
22:33
课时15：6.15The β-globin region
13:48
课时16：6.16Transcription and Translation
05:14
课时17：6.17Lac Operon
05:15
课时18：6.18How to Edit a Gene
04:21
第7章:DNA重组和基因的克隆分析
课时1：7.1Introduction
00:38
课时2：7.2Overview
11:32
课时3：7.3Cutting and Pasting DNA
21:41
课时4：7.4Vectors
09:19
课时5：7.5Transformation and Selection
10:25
课时6：7.6Shaggy Dog
04:43
课时7：7.7Week's Introduction
00:46
课时8：7.8Tricks for Cloning
14:49
课时9：7.9Different Cloning Vectors and Source DNA
09:20
课时10：7.10Finding Your Gene by Complementation
10:45
课时11：7.11Finding Your Gene by Protein Expression
20:22
课时12：7.12Gel Electrophoresis
13:46
课时13：7.13DNA Sequencing, the Concept
12:00
课时14：7.14DNA Sequencing, Implementation
19:41
课时15：7.15Polymerase Chain Reaction (PCR)
14:16
课时16：7.16Lab Video∶ Gel Electrophoresis
05:28
课时17：7.17Origin of Replication and Promoters
03:41
课时18：7.18Restriction Enzymes
04:48
第8章:基因组-人类基因组
课时1：8.1Weekly Introduction
01:02
课时2：8.2Recombinant DNA Review
08:00
课时3：8.3Finding Your Gene∶ Human Mendelian Diseases
11:24
课时4：8.4Genetic Mapping in Humans
26:48
课时5：8.5The Human Genome Project∶ Genome assembly and analysis
16:36
课时6：8.6Improvements since the Human Genome Project
08:16
课时7：8.7Improvements in DNA Sequencing
11:18
课时8：8.8The Genomic Landscape
21:14
课时9：8.9Evolutionary Comparisons
14:41
课时10：8.10Evolutionary Comparisons as a Tool for Biomedical Research
17:43
课时11：8.11DNA Polymorphisms within Human Populations
21:47
课时12：8.12Sanger Sequencing
05:50
课时13：8.13New Sequencing Technologies
05:38
第9章:基因组学观察和扰动的基因组探针功能
课时1：9.1Weekly Introduction
00:53
课时2：9.2DNA Polymorphisms in Medicine∶ Taking a Comprehensive View
19:57
课时3：9.3DNA Polymorphisms∶ Polygenic Diseases
19:27
课时4：9.4RNA Variation
15:42
课时5：9.5Protein Localization on the Genome
04:40
课时6：9.6Adding a Gene
04:29
课时7：9.7Modifying and Subtracting a Gene
31:48
课时8：9.8RNA Interference
10:18
课时9：9.9Modern Genome Editing
16:22
第10章:疾病和科学与社会
课时1：10.1Weekly Introduction
01:26
课时2：10.2Heart Disease
08:42
课时3：10.3Cholesterol
07:40
课时4：10.4Lipoprotein Particles and the Connection to Heart Disease
14:10
课时5：10.5The Genetics of Cholesterol Levels
13:54
课时6：10.6Rational Therapy for Familial Hypercholesterolemia
15:27
课时7：10.7Modern Strategies
09:13
课时8：10.8Cancer
13:39
课时9：10.9Regulation of Cell Growth – Growth Factors and Receptors
09:20
课时10：10.10Regulation of Cell Growth - Ras
06:09
课时11：10.11Regulation of Cell Growth – Ras Signaling
07:07
课时12：10.12Mutations that Cause Cancer
14:53
课时13：10.13Anti-Cancer Therapy
17:04
课时14：10.14DNA Fingerprinting
13:34
课时15：10.15DNA and Law
19:07
课时16：10.16Other Forensic Technologies
20:07
课时17：10.17Gene Patenting
38:44
课时18：10.18Lecture 24 Update
01:06
课时19：10.19Cancer Biology 1
05:01
课时20：10.20Cancer Biology 2
02:37
第11章:Lander教授的告别
课时1：11Farewell Message and Credits
09:42
第12章:实践考试1：生物化学和遗传学
课时1：12Exam Message from Professor Lander
00:26
第13章:实践考试2：分子生物学和基因重组
课时1：13Message from Professor Lander
00:26
兰州大学
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